# Lorea

> Lorea is an AI-powered study platform that transforms PDFs into interactive study materials — games, quizzes, videos, songs, podcasts, summaries, and more. Free for students.

## Study Tools

- [PDF to Multiple Choice](https://www.lorea.app/pdf-to-multiple-choice): Generate practice MCQs from any PDF
- [PDF to Summary](https://www.lorea.app/pdf-to-summary): Condense dense material into concise study notes
- [PDF to Mock Exam](https://www.lorea.app/pdf-to-mock-exam): Create timed practice exams from your notes
- [PDF to Game](https://www.lorea.app/pdf-to-game): Turn study material into interactive games
- [PDF to Study Songs](https://www.lorea.app/pdf-to-study-songs): Convert notes into memorable study songs
- [PDF to Podcasts](https://www.lorea.app/pdf-to-podcasts): Listen to your study material as audio
- [PDF to AI Video](https://www.lorea.app/pdf-to-ai-video): Generate cinematic study videos from PDFs
- [Subway Surfers Study Tool](https://www.lorea.app/subway-surfers-study-tool): Brainrot-style study videos with Subway Surfers gameplay
- [Clash Royale Study Tool](https://www.lorea.app/clash-royale-study-tool): Brainrot-style study videos with Clash Royale gameplay
- [Learn with LeBron AI](https://www.lorea.app/learn-with-lebron-ai): LeBron-style AI study videos with narration and viral captions
- [PDF to Fairytale](https://www.lorea.app/pdf-to-fairytale): Turn any PDF into a magical fairytale study video — pick an owl, hamster, or giraffe avatar — AI fable generator that turns notes into educational stories

## Free Resources

- [Free Worksheet Generator](https://www.lorea.app/free-worksheet-generator): Create worksheets from any topic
- [Free Flashcard Generator](https://www.lorea.app/free-flashcard-generator): Generate flashcard decks instantly
- [Free Essay Grader](https://www.lorea.app/free-essay-grader): Get AI feedback on essays
- [PowerPoint to Notes AI](https://www.lorea.app/powerpoint-to-notes): Convert any PPTX to structured study notes with AI
- [PowerPoint to Study Guide](https://www.lorea.app/powerpoint-to-study-guide): Turn any PowerPoint into a comprehensive exam-ready study guide

## Exam Games

- [Exam Games Hub](https://www.lorea.app/exam-games): Free interactive exam-prep games for the MCAT and ATI TEAS — topic-by-topic active recall mapped to official content outlines
- [MCAT Games](https://www.lorea.app/exam-games/mcat): 130+ free interactive MCAT review games covering every AAMC content category — Biochemistry (glycolysis, Krebs, ETC, enzyme kinetics), Bio/Molecular (DNA replication, transcription, translation), Human Physiology (nervous, cardiovascular, renal, immune), General Chemistry, Organic Chemistry, Physics, Psychology and Sociology
- [ATI TEAS Games](https://www.lorea.app/exam-games/ati-teas): Free ATI TEAS 7 prep games for nursing program admission — Reading, Mathematics, Science (anatomy & physiology, life science, physical science, scientific reasoning), English & Language Usage
- [Sarcomere & Sliding Filament Tournament](https://www.lorea.app/exam-games/ati-teas/sarcomere-sliding-filament-game): Public 5-round TEAS A&P tournament (labeling, fill-in-the-blank, disruptor, hot spot, length-tension graph) on sarcomere structure and the sliding filament theory of muscle contraction. Uses the live Reactome Striated Muscle Contraction pathway diagram (R-HSA-390522, CC BY 4.0). No signup; randomized tournament name; scores saved in browser; public global leaderboard.
- [Glycolysis Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/glycolysis-game): Public 5-round MCAT-DoK biochemistry tournament on glycolysis - identifying PFK-1 as the rate-limiting enzyme on the live Reactome Glucose Metabolism diagram (R-HSA-70326, CC BY 4.0), the role of PGK and GAPDH in substrate-level phosphorylation and NADH production, predicting the consequence of arsenate poisoning at GAPDH, and reading hexokinase vs glucokinase Michaelis-Menten kinetics. No signup; public global leaderboard.
- [Citric Acid Cycle (Krebs) Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/citric-acid-cycle-game): Public 5-round MCAT-DoK biochemistry tournament on the citric acid cycle - identifying the alpha-ketoglutarate dehydrogenase complex on the live Reactome TCA Cycle diagram (R-HSA-71403, CC BY 4.0), the role of succinyl-CoA synthetase in substrate-level phosphorylation, the consequence of Complex I inhibition (rotenone) on TCA flux, the dual role of succinate dehydrogenase as ETC Complex II, and computing total ATP equivalents per acetyl-CoA from a yield table. No signup; public global leaderboard.
- [Electron Transport Chain Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/electron-transport-chain-game): Public 10-round MCAT-DoK tournament on the mitochondrial ETC - identifying Complex IV (cytochrome c oxidase) on the live Reactome Respiratory Electron Transport diagram (R-HSA-611105, CC BY 4.0) and WikiPathways WP623, walking electron flow NADH -> Complex I -> Q -> Complex III -> cyt c -> Complex IV -> O2, calculating proton stoichiometry (4 + 4 + 2 = 10 H+ per NADH), reasoning about cyanide / rotenone / antimycin A inhibitors and their crossover points, and the role of Complex II as a non-pumping entry point for FADH2. No signup; public global leaderboard.
- [Oxidative Phosphorylation Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/oxidative-phosphorylation-game): Public 10-round MCAT-DoK tournament on chemiosmosis and ATP synthase - identifying the ATP synthase F1F0 complex on Reactome (R-HSA-163200) and WikiPathways WP111, computing P/O ratios (~2.5 NADH, ~1.5 FADH2), reasoning about uncouplers (DNP, thermogenin/UCP1) and oligomycin, the proton motive force as the sum of pH gradient and membrane potential, and the rotational catalysis mechanism. No signup; public global leaderboard.
- [Pentose Phosphate Pathway Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/pentose-phosphate-pathway-game): Public 10-round MCAT-DoK tournament on the PPP / HMP shunt - identifying glucose-6-phosphate dehydrogenase (G6PD) as the rate-limiting enzyme on Reactome (R-HSA-71336) and WikiPathways WP134, the dual outputs NADPH (for fatty acid synthesis, glutathione reduction, ROS defense) and ribose-5-phosphate (for nucleotide synthesis), reasoning about G6PD deficiency and hemolysis precipitated by primaquine / fava beans / sulfa drugs, and the irreversible oxidative vs reversible non-oxidative branches. No signup; public global leaderboard.
- [Gluconeogenesis Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/gluconeogenesis-game): Public 10-round MCAT-DoK tournament on hepatic gluconeogenesis - identifying the four bypass enzymes pyruvate carboxylase / PEPCK / fructose-1,6-bisphosphatase / glucose-6-phosphatase on Reactome (R-HSA-70263) and WikiPathways WP534, reasoning about the Cori cycle and alanine cycle, the energy cost (6 ATP equivalents / glucose), reciprocal regulation by F2,6BP, and why fatty acids cannot be converted to glucose in mammals. No signup; public global leaderboard.
- [Glycogenesis & Glycogenolysis Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/glycogenesis-glycogenolysis-game): Public 10-round MCAT-DoK tournament on glycogen metabolism - identifying glycogen phosphorylase as the rate-limiting enzyme of glycogenolysis on Reactome (R-HSA-70221) and WikiPathways WP500, the role of glycogen synthase, branching/debranching enzymes, hormonal regulation (epinephrine -> liver vs muscle, glucagon -> liver only), reasoning about glycogen storage diseases (von Gierke, Pompe, McArdle), and the difference between hepatic glucose export and muscle anaerobic glycolysis. No signup; public global leaderboard.
- [Fatty Acid Beta-Oxidation Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/fatty-acid-oxidation-game): Public 10-round MCAT-DoK tournament on fatty acid catabolism - identifying carnitine palmitoyltransferase I (CPT1) as the regulated mitochondrial entry step on Reactome (R-HSA-77289) and WikiPathways WP143, the four-step beta-oxidation cycle (oxidation, hydration, oxidation, thiolysis), calculating ATP yield from palmitate (~106 ATP), reasoning about MCAD deficiency and the carnitine shuttle, malonyl-CoA inhibition of CPT1, and ketogenesis under prolonged fasting. No signup; public global leaderboard.
- [Fatty Acid Synthesis Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/fatty-acid-synthesis-game): Public 10-round MCAT-DoK tournament on de novo lipogenesis - identifying acetyl-CoA carboxylase (ACC) as the rate-limiting cytosolic enzyme on Reactome (R-HSA-75109) and WikiPathways WP357, the citrate shuttle for moving acetyl-CoA out of the mitochondrion, the seven-domain mammalian fatty acid synthase, NADPH from PPP and malic enzyme, reciprocal regulation of ACC vs CPT1 by malonyl-CoA, and the maximum 16-carbon palmitate product. No signup; public global leaderboard.
- [DNA Replication Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/dna-replication-game): Public 10-round MCAT-DoK molecular biology tournament on prokaryotic and eukaryotic DNA replication - identifying DNA polymerase delta on Reactome (R-HSA-69306) and WikiPathways WP466, the leading vs lagging strand asymmetry and Okazaki fragments, the roles of helicase / SSB / topoisomerase / primase / DNA pol III & I / ligase, semiconservative replication (Meselson-Stahl), 3' to 5' exonuclease proofreading, telomerase and the end replication problem, reasoning about ddNTP chain termination (acyclovir, AZT). No signup; public global leaderboard.
- [Transcription Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/transcription-game): Public 10-round MCAT-DoK tournament on eukaryotic transcription - identifying RNA polymerase II on Reactome (R-HSA-73857) and WikiPathways WP1591, the three RNA pols (I = rRNA, II = mRNA, III = tRNA / 5S rRNA), the TATA box / Mediator / general transcription factors, reasoning about alpha-amanitin and rifampin selectivity, the three co-transcriptional mRNA processing steps (5' capping, splicing, 3' poly-A tail), spliceosome and snRNPs, and operon vs eukaryotic regulation. No signup; public global leaderboard.
- [Translation Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/translation-game): Public 10-round MCAT-DoK molecular biology tournament on translation - identifying the 80S eukaryotic ribosome on Reactome (R-HSA-72766) and WikiPathways WP107, walking the cycle from 43S pre-initiation complex through cap-dependent scanning to 80S assembly, elongation (eEF1A delivery, peptide bond formation by 28S rRNA peptidyl transferase, eEF2 translocation), and termination (eRF1, eRF3), prokaryotic vs eukaryotic ribosome architecture (70S vs 80S, fMet vs Met, Shine-Dalgarno vs Kozak), the wobble hypothesis, and reasoning about aminoglycoside / macrolide / chloramphenicol / tetracycline antibiotics and diphtheria toxin (eEF2 ADP-ribosylation). No signup; public global leaderboard.
- [Pyruvate Dehydrogenase Complex Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/pyruvate-dehydrogenase-complex-game): Public 10-task MCAT-DoK tournament on the pyruvate dehydrogenase complex - oriented by the Reactome aerobic-respiration overview (R-HSA-1428517) and WikiPathways WP78, then 8 non-visual quiz rounds on PDC's five cofactors (TPP/lipoate/CoA/FAD/NAD+), E1-E2-E3 mechanism, PDK/PDP regulation by acetyl-CoA + NADH + Ca2+ + insulin, thiamine deficiency and Wernicke encephalopathy, lactic-acidosis logic, and arsenite poisoning of the lipoamide arm. No signup; public global leaderboard.
- [Urea Cycle Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/urea-cycle-game): Public 10-task MCAT-DoK tournament on the urea cycle - oriented by the Reactome amino-acid-metabolism overview (R-HSA-71291) and WikiPathways WP4225, then 8 non-visual quiz rounds on CPS I as rate-limiting and N-acetylglutamate-dependent, OTC deficiency vs citrullinemia, the carbamoyl-phosphate -> citrulline -> argininosuccinate -> arginine -> urea + ornithine path, the 4-ATP cost per urea, hyperammonemia neurotoxicity via astrocyte alpha-KG depletion, and ammonia-scavenger pharmacology (sodium phenylbutyrate, benzoate). No signup; public global leaderboard.
- [Amino Acid Catabolism & Inborn Errors Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/amino-acid-catabolism-game): Public 10-task MCAT-DoK tournament on amino-acid catabolism + inborn errors - oriented by the Reactome whole-cell-metabolism overview (R-HSA-1430728) and WikiPathways WP2197 (Phe-Tyr pathway), then 8 non-visual quiz rounds on PKU and BH4 logic, alkaptonuria's homogentisate oxidase block, MSUD's branched-chain alpha-ketoacid dehydrogenase, classic homocystinuria from cystathionine beta-synthase deficiency, methylmalonic acidemia from methylmalonyl-CoA mutase + B12, ketogenic vs glucogenic amino acids (Lys + Leu pure-K), and the B6 transamination + glutamine/alanine N-carrier system. No signup; public global leaderboard.
- [Ketone Body Metabolism Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/ketone-body-metabolism-game): Public 10-task MCAT-DoK tournament on ketone bodies - oriented by the Reactome lipid-metabolism overview (R-HSA-556833) and WikiPathways WP143, then 8 non-visual quiz rounds on HMG-CoA synthase as rate-limiting ketogenesis enzyme, beta-OH-butyrate as the dominant fasting ketone, why liver makes but cannot use ketones (lacks thiophorase), DKA biochemistry in T1DM, the canonical ~21 ATP yield from full BHB oxidation, the BHB / acetoacetate ratio as a NADH/NAD+ readout, and MCAD deficiency's paradoxical hypoketotic hypoglycemia. No signup; public global leaderboard.
- [Cholesterol Biosynthesis & Statins Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/cholesterol-biosynthesis-game): Public 10-task MCAT-DoK tournament on cholesterol biosynthesis + statin pharmacology - oriented by the Reactome lipid-metabolism overview (R-HSA-556833) and WikiPathways WP197, then 8 non-visual quiz rounds on HMG-CoA reductase as rate-limiting and the statin target, the mevalonate -> IPP -> FPP -> squalene -> lanosterol -> cholesterol path, why statins lower LDL via SREBP-2-driven LDLR upregulation, the 18-acetyl-CoA arithmetic of cholesterol's C27 backbone, AMPK phosphorylation of HMG-CoA reductase, ezetimibe / PCSK9 inhibitor / bile acid sequestrant mechanisms, and familial hypercholesterolemia from LDLR mutations. No signup; public global leaderboard.
- [Heme Biosynthesis & Porphyrias Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/heme-biosynthesis-game): Public 10-task MCAT-DoK tournament on heme biosynthesis + porphyrias - oriented by the Reactome whole-cell-metabolism overview (R-HSA-1430728) and WikiPathways WP561, then 8 non-visual quiz rounds on ALA synthase as rate-limiting and B6-dependent, the 8-step pathway alternating between mitochondrion (start, end) and cytosol (middle four), lead poisoning's dual block of ALA dehydratase + ferrochelatase (basophilic stippling, zinc protoporphyrin), AIP triggers via P450-induced heme depletion, PCT's photosensitivity from uroporphyrinogen decarboxylase deficiency, ALAS1 (ubiquitous) vs ALAS2 (erythroid + iron-responsive) isoforms, and heme degradation through CO + biliverdin + bilirubin. No signup; public global leaderboard.
- [Purine Metabolism Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/purine-metabolism-game): Public 10-task MCAT-DoK tournament on purine metabolism + uric acid - oriented by the Reactome whole-cell-metabolism overview (R-HSA-1430728) and WikiPathways WP404, then 8 non-visual quiz rounds on glutamine-PRPP amidotransferase as the committed de novo step, HGPRT loss in Lesch-Nyhan syndrome, the AMP -> hypoxanthine -> xanthine -> uric acid catabolic path, allopurinol + febuxostat as xanthine oxidase inhibitors, the allopurinol / 6-MP drug interaction, ADA-SCID and PNP-deficiency immunology, and tumor-lysis syndrome biochemistry with rasburicase prophylaxis. No signup; public global leaderboard.
- [Cell Cycle & Mitosis Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/cell-cycle-mitosis-game): Public 10-task MCAT-DoK tournament on the cell cycle and mitosis - oriented by the Reactome cell-cycle overview (R-HSA-69278) and WikiPathways WP179, then 8 non-visual quiz rounds on Rb-E2F at the G1/S restriction point, cyclin D-CDK4/6 + cyclin E-CDK2 + cyclin A-CDK2 + cyclin B-CDK1 phase pairings, the spindle assembly checkpoint and paclitaxel mechanism, APC/C-driven metaphase-to-anaphase transition, the chromatid arithmetic of S phase (2N=46 -> 92 chromatids), p53 / p21 DNA-damage response, and Li-Fraumeni syndrome from germline TP53 loss. No signup; public global leaderboard.
- [Apoptosis Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/apoptosis-game): Public 10-task MCAT-DoK tournament on apoptosis - oriented by the Reactome programmed-cell-death overview (R-HSA-5357801) and WikiPathways WP254, then 8 non-visual quiz rounds on cytochrome c's apoptosome role with Apaf-1 + dATP + caspase-9, t(14;18) BCL2 overexpression in follicular lymphoma, intrinsic-pathway choreography from p53 -> Bax/Bak -> MOMP -> caspase-3, the Bcl-2 family hierarchy (anti-apoptotic + effectors + BH3-only sensors), the heptameric apoptosome architecture, apoptosis vs necrosis morphology (membrane integrity, ATP-dependence, PS externalization, DNA laddering), and Fas mutations causing autoimmune lymphoproliferative syndrome. No signup; public global leaderboard.
- [GPCR Signaling Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/gpcr-signaling-game): Public 10-task MCAT-DoK tournament on G-protein-coupled-receptor signaling - oriented by the Reactome signal-transduction overview (R-HSA-162582) and WikiPathways WP35, then 8 non-visual quiz rounds on Gαs/Gαi/Gαq family-effector pairings, adenylate cyclase + cAMP + PKA + CREB, cholera and pertussis toxin ADP-ribosylation tricks, the canonical 7-step cascade from ligand binding to gene expression, the 7-transmembrane receptor architecture, GRK + β-arrestin desensitization driving tachyphylaxis, biased agonism, and the contrast with insulin's receptor-tyrosine-kinase signaling. No signup; public global leaderboard.

- [MAPK / Ras Signaling Cascade Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/mapk-ras-signaling-game): Public 10-task MCAT tournament on the prototype mitogenic three-tier kinase module - oriented by Reactome signal transduction (R-HSA-162582) and WikiPathways WP382, then 8 non-visual quiz rounds on Raf as the Ras-binding MAP3K, BRAF V600E in melanoma + vemurafenib resistance, the canonical RTK -> Grb2 -> SOS -> Ras -> Raf -> MEK -> ERK choreography, the three-tier MAP3K -> MAP2K -> MAPK architecture, scaffolds + DUSPs for negative feedback, and NF1 / neurofibromatosis as the textbook RASopathy. No signup; public leaderboard.

- [Insulin & RTK Signaling Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/insulin-rtk-signaling-game): Public 10-task MCAT tournament on receptor tyrosine kinase signaling - oriented by Reactome signal transduction (R-HSA-162582) and WikiPathways WP481, then 8 non-visual quiz rounds on IRS-1/2 as insulin's unique adaptor, T2DM mTORC1/JNK Ser-phosphorylation insulin resistance, the canonical IR -> IRS -> PI3K -> PIP3 -> Akt -> AS160 -> GLUT4 sequence, the constitutive α2β2 receptor architecture, downstream metabolic effects (FOXO exclusion, GSK3 inhibition, anti-lipolysis), PTEN as PIP3 phosphatase, and Donohue / leprechaunism. No signup; public leaderboard.

- [Wnt Signaling Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/wnt-signaling-game): Public 10-task MCAT tournament on canonical Wnt / β-catenin signaling - oriented by Reactome signal transduction and WikiPathways WP428, then 8 non-visual quiz rounds on the Axin/APC/GSK3/CK1 destruction complex, APC loss in familial adenomatous polyposis + colorectal cancer, the Wnt -> Frizzled/LRP5/6 -> Dvl -> destruction-complex disassembly -> nuclear β-catenin -> TCF/LEF sequence, Frizzled's 7-TM architecture, DKK1 as Wnt antagonist, romosozumab + sclerostin in osteoporosis, and osteoporosis-pseudoglioma syndrome from LRP5 loss. No signup; public leaderboard.

- [Notch Signaling Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/notch-signaling-game): Public 10-task MCAT tournament on regulated intramembrane proteolysis - oriented by Reactome signal transduction and WikiPathways WP268, then 8 non-visual quiz rounds on γ-secretase cleavage releasing NICD, NOTCH1 gain-of-function in T-ALL + γ-secretase inhibitor toxicity, the Delta/Jagged -> ADAM10/17 (S2) -> γ-secretase (S3) -> NICD -> CSL/RBPJ -> Mastermind sequence, juxtacrine cell-cell signaling, lateral inhibition in development, CADASIL from NOTCH3, and Alagille syndrome from JAG1 haploinsufficiency. No signup; public leaderboard.

- [Hedgehog Signaling Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/hedgehog-signaling-game): Public 10-task MCAT tournament on Hedgehog signaling - oriented by Reactome signal transduction and WikiPathways WP47, then 8 non-visual quiz rounds on Patched as the SMO-inhibiting receptor, vismodegib + sonidegib in basal cell carcinoma, the Shh -> Patched (out) -> Smoothened (in) -> SuFu inhibition release -> Gli activator -> nucleus sequence in the primary cilium, Patched's 12-TM architecture, cyclopamine + holoprosencephaly, and Gorlin syndrome from PTCH1 loss. No signup; public leaderboard.

- [DNA Repair Mechanisms Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/dna-repair-game): Public 10-task MCAT tournament on the five major DNA repair pathways - oriented by Reactome's DNA repair overview (R-HSA-73894) and WikiPathways WP4946, then 8 non-visual quiz rounds on NER and xeroderma pigmentosum, MMR + Lynch syndrome (MLH1/MSH2 + MSI tumors + checkpoint inhibitor responsiveness), the BER glycosylase -> APE1 -> Pol β -> ligase sequence, HR vs NHEJ for double-strand breaks, BRCA1/2 + PARP inhibitor synthetic lethality, MGMT in temozolomide / glioblastoma, and Fanconi anemia from FANC interstrand cross-link repair defects. No signup; public leaderboard.

- [Hemostasis & Coagulation Cascade Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/hemostasis-coagulation-game): Public 10-task MCAT tournament on primary + secondary hemostasis - oriented by Reactome's Hemostasis overview (R-HSA-109582) and a curated WikiPathways figure, then 8 non-visual quiz rounds on tissue factor as the in-vivo trigger, hemophilia A vs. B and the PT/aPTT framework, the canonical primary platelet plug + fibrin clot sequence, the four vitamin-K-dependent factors (II/VII/IX/X), heparin/warfarin/DOACs/aspirin/P2Y12/eculizumab pharmacology, antithrombin III + protein C + Factor V Leiden + tPA, and DIC from sepsis. No signup; public leaderboard.

- [Innate Immunity & TLR Signaling Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/tlr-innate-immunity-game): Public 10-task MCAT tournament on innate immunity and Toll-like receptors - oriented by Reactome's Innate Immune System overview (R-HSA-168249) and WikiPathways WP75, then 8 non-visual quiz rounds on TLR4 / LPS recognition (CD14 + MD-2), the canonical MyD88 -> IRAK -> TRAF6 -> IKK -> NF-κB axis, full TLR4 LPS-to-cytokine sequence, PRR landscape (TLRs, NLRs, RIG-I, inflammasome), the 10 human TLRs and their PAMPs, NK cells + DAMPs + interferons, TCR vs PRR contrast, and septic shock + iNOS-driven hypotension. No signup; public leaderboard.

- [Complement Cascade Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/complement-cascade-game): Public 10-task MCAT tournament on the complement system - oriented by Reactome's Innate Immune System overview (R-HSA-168249) and WikiPathways WP545, then 8 non-visual quiz rounds on C3 convertase as the central node, hereditary angioedema as bradykinin-mediated C1-INH loss, the canonical classical-pathway sequence to MAC insertion, opsonization vs. anaphylatoxins vs. MAC roles, the three activation pathways, regulators (DAF/CD59 + Factor H) and Neisseria infections in late-component deficiency, complement vs. clotting nomenclature, and PNH from PIGA loss treated by eculizumab. No signup; public leaderboard.

- [Meiosis & Genetic Variability Tournament (MCAT)](https://www.lorea.app/exam-games/mcat/meiosis-genetic-variability-game): Public 10-task MCAT tournament on meiosis - oriented by Reactome's Cell Cycle overview (R-HSA-1640170) and WikiPathways WP4655, then 8 non-visual quiz rounds on crossing over in pachytene, maternal MI nondisjunction in trisomy 21 + the maternal-age effect, the S-phase -> MI (homologs) -> MII (sister chromatids) sequence, the three sources of variability (crossing over + independent assortment + random fertilization), 2^23 chromosome combinations, sex-specific gametogenesis with oocyte arrest, mitosis vs. meiosis contrast, and Prader-Willi vs. Angelman as parent-of-origin imprinting. No signup; public leaderboard.

## Study Materials

- [Study Materials Hub](https://www.lorea.app/study): Browse all subject-specific study tools
- [Nursing Study Materials](https://www.lorea.app/study/nursing): NGN case studies, dosage calculations, NCLEX prep
- [Medicine Study Materials](https://www.lorea.app/study/medicine): USMLE clinical vignettes, pharmacology, Step 2 CK
- [Law Study Materials](https://www.lorea.app/study/law): IRAC case briefs, MBE practice questions
- [Biology Study Materials](https://www.lorea.app/study/biology): WASSCE practice, glycolysis game, amino acids game
- [WASSCE Biology Questions 2019](https://www.lorea.app/study/biology/wassce-biology-questions-2019): Practice WASSCE biology exam questions
- [Glycolysis Game](https://www.lorea.app/study/biology/glycolysis-game): Interactive glycolysis practice
- [Amino Acids Game](https://www.lorea.app/study/biology/amino-acids-game): Interactive amino acids practice
- [Enzyme Game](https://www.lorea.app/study/biology/enzyme-game): Interactive enzyme kinetics and inhibition practice
- [Mitosis Game](https://www.lorea.app/study/biology/mitosis-game): Interactive cell division (mitosis) practice
- [Meiosis Game](https://www.lorea.app/study/biology/meiosis-game): Interactive meiosis and genetic variation practice
- [Cell Cycle Study Guide](https://www.lorea.app/study/biology/cell-cycle): Complete 5-chapter interactive cell cycle course (interphase, mitosis, cytokinesis, regulation, game, study guide)
- [Forensic Science Course](https://www.lorea.app/study/biology/forensic-science): Complete 5-chapter forensic science course (evidence collection, DNA profiling, toxicology, entomology, game, study guide)
- [Protein Synthesis Course](https://www.lorea.app/study/biology/protein-synthesis): Complete 5-chapter protein synthesis course (transcription, translation, post-translational modifications, gene regulation, game, study guide)
- [Integumentary System Course](https://www.lorea.app/study/biology/integumentary-system): Complete 5-chapter integumentary system course (epidermis, dermis, skin appendages, skin conditions, wound healing, game, study guide)
- [AP Biology Course](https://www.lorea.app/study/biology/ap-biology): Complete 10-chapter AP Biology course (introduction, chemistry of life, cell structure & function, cellular energetics, cell communication, cell division, heredity & genetics, gene expression & regulation, evolution & natural selection, ecology & populations; AP biology game, study guide; Wikimedia Commons figures, PubChem structures, flow diagrams, inline quizzes, fill-in-the-blank)
- [Histology Course](https://www.lorea.app/study/biology/histology): Complete 5-chapter histology course (introduction and tissue preparation, epithelial tissue, connective tissue, muscle and nervous tissue, stains and laboratory methods; histology game, study guide; PubChem structures, Wikimedia Commons micrographs, inline quizzes, tables, and flow-style section diagrams)
- [Endocrine System Course](https://www.lorea.app/study/medicine/endocrine-system): Complete 5-chapter endocrine system course (hypothalamus & pituitary, thyroid & parathyroid, adrenal glands, pancreas & blood sugar, game, study guide)
- [Physiology Course](https://www.lorea.app/study/medicine/physiology): Complete 5-chapter medicine physiology course (introduction, membrane transport & resting potential, cardiovascular physiology, respiratory physiology, renal physiology & fluid balance; physiology game, study guide; Wikimedia Commons figures, PubChem structures, pathway diagrams, inline quizzes, fill-in-the-blank)
- [Anatomy Course](https://www.lorea.app/study/medicine/anatomy): Complete 5-chapter medicine anatomy course (introduction, skeletal system & joints, thorax & abdomen, pelvis & perineum, head neck & neuroanatomy; anatomy game, study guide; Wikimedia Commons figures, PubChem structures, flow diagrams, inline quizzes, fill-in-the-blank)
- [Biochemistry Study Materials](https://www.lorea.app/study/biochemistry): Glycogenesis course, interactive games, quizzes, and study guides
- [Glycogenesis Course](https://www.lorea.app/study/biochemistry/glycogenesis): Complete 5-chapter interactive glycogenesis course (glycogen structure, key enzymes, regulation, glycogen storage diseases, game, study guide)
- [Protein Physics & Bioenergetics Course](https://www.lorea.app/study/biochemistry/protein-physics): 5-chapter course on biochemical thermodynamics, ATP, amino acid ionization, secondary structure, and the Ramachandran plot - with PubChem molecular structures
- [NCLEX Question Generator](https://www.lorea.app/study/nursing/nclex-question-generator): AI-powered NCLEX practice question generator

## Blog

- [Blog](https://www.lorea.app/blog): Study strategies, exam guides, and learning tips
- [NCLEX NGN Case Studies Guide](https://www.lorea.app/blog/nursing/how-to-pass-nclex-ngn-case-studies)
- [Nursing Dosage Calculation Guide](https://www.lorea.app/blog/nursing/nursing-dosage-calculation-guide)
- [NCLEX-RN 30-Day Study Plan](https://www.lorea.app/blog/nursing/nclex-rn-30-day-study-plan)
- [How to Challenge the IPN Exam in Florida](https://www.lorea.app/blog/nursing/how-to-challenge-ipn-exam-florida): Complete guide to challenging the IPN exam in Florida - eligibility, study strategies, exam format, and free practice tools
- [Memorize Anatomy with Spatial Memory](https://www.lorea.app/blog/medical/memorize-anatomy-spatial-memory)
- [USMLE Clinical Vignettes Strategy](https://www.lorea.app/blog/medical/usmle-clinical-vignettes-strategy)
- [How to Write an IRAC Case Brief](https://www.lorea.app/blog/law/how-to-write-irac-case-brief)
- [How to Prepare for the MBE](https://www.lorea.app/blog/law/how-to-prepare-for-mbe)
- [Constitutional Law Cases for Law Students](https://www.lorea.app/blog/law/constitutional-law-cases-law-students)
- [Turn Textbooks Into Q-Banks](https://www.lorea.app/blog/strategies/textbooks-to-qbanks-fast)
- [3D Study World Guide](https://www.lorea.app/blog/strategies/3d-study-world-guide)
- [How to Color Code Notes](https://www.lorea.app/blog/strategies/how-to-color-code-notes)
- [Best Time to Study: Morning vs Night](https://www.lorea.app/blog/strategies/best-time-to-study): Science-backed guide to the best time to study, chronotypes, peak study hours, sleep, and building a study schedule

## Comparisons

- [Best AI Study Tools 2026](https://www.lorea.app/alternatives): Honest comparison of 15+ study platforms
- [Khan Academy Alternative](https://www.lorea.app/alternatives/khan-academy): Best Khan Academy alternative in 2026
- [All Head-to-Head Comparisons](https://www.lorea.app/compare): Lorea vs every major study tool